Human Recombinant Mcam
Price:
$822.72
Product Name : Human Recombinant Mcam
CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.
As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.
As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
| Protein/peptide name | Mcam |
| Protein synonyms | MCAM,MUC18,CD146 |
| Protein/peptide type | Recombinant |
| Species | Human |
| Source | HEK293 cells |
| Purity | >95% as determined by SDS-PAGE. |
| Formulation | Lyophilized, 50 mM tris, 100 mM glycine, pH7.5 |
| Molecular weight | 85.9 kDa |
| Fusion | C-Fc Tag |
| Tested applications | Western Blot |
| Molecular weight | 85.9 kDa |
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