Human Recombinant Mcam


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Product Name : Human Recombinant Mcam

CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells.
As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
Protein/peptide name Mcam
Protein synonyms MCAM,MUC18,CD146
Protein/peptide type Recombinant
Species Human
Source HEK293 cells
Purity >95% as determined by SDS-PAGE.
Formulation Lyophilized, 50 mM tris, 100 mM glycine, pH7.5
Molecular weight 85.9 kDa
Fusion C-Fc Tag
Tested applications Western Blot
Molecular weight 85.9 kDa
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